---
title: Ghost Cytometry for Functional Genomics Screening
description: Discover how Ghost Cytometry streamlines functional genomics screening by using pooled phenotypic analysis to identify cells that inhibit NFkB translocation in response to LPS stimulation.
---

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**Ghost Cytometry  
for Functional Genomics Screening**

![Screenshot 2025-01-17 095358](https://info.thinkcyte.com/hubfs/Assets/Screenshot%202025-01-17%20095358.jpg "Screenshot 2025-01-17 095358")

Introduction:

Functional genomics requires a rapid and unbiased screening platforms to identify phenotypic changes after genetic manipulation. Here we show the use of VisionSort, powered by Ghost Cytometry (GC) technology, as a novel approach to enable phenotypic screening in flow using NFkB translocation as a model phenotype. 

Summary:

1. VisionSort can create machine learning models to recognize specialized molecular phenotypes
2. VisionSort was able to create a machine learning model to identify known mediators of NFkB signalling in a proof-of-concept CRISPR screen
3. VisionSort enables functional genomics screening without the need for single cell plating – significantly increasing throughput and reducing time to results 

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